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The branded GLP-1 medications approved for chronic weight management Wegovy, Zepbound, Saxenda, and now Foundayo sit on payer formularies as some of the most expensive new drugs of the decade

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S5 show that GLP-1RA were associated with lower risks as compared with placebo (16% lower risk), DPP-4 inhibitors (15% lower risk) and SGLT-2 inhibitors (10% lower risk), but the difference was statistically significant as compared with placebo only