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Neurons, along with other high-energy-demand cells, are highly reliant on mitochondrial energy production, and inadequate ATP levels may compromise the efficiency of synaptic transmission (70), Furthermore, insufficient ATP activates a cellular stress response via the AMP-activated protein kinase (AMPK) signaling pathway (71, 72), suppressing non-essential metabolic processes (73), regulating mitochondrial biogenesis, and modulating autophagy (74) to conserve energy resources

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Keywords: pentadecapeptide BPC-157, wound healing, human umbilical vein endothelial cells, ERK1/2 signaling pathway Introduction Wound healing is a very complicated pathophysiologic process

Most peptides are subcutaneous and straightforward to self-administer