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We do not know the optimal human dosing, long-term safety profile in humans, or whether animal results translate directly to human outcomes

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BEST PRACTICES BOX: COMPREHENSIVE METABOLIC AND MITOCHONDRIAL MONITORING Establish baseline measurements of body composition (DEXA or bioimpedance), metabolic rate (indirect calorimetry if available), fasting glucose and insulin (HOMA-IR calculation), glucose tolerance testing, lipid profile, and exercise capacity (VO2max or time-to-exhaustion testing)