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When to seek urgent medical attention : Severe, persistent abdominal pain (possible pancreatitis) Suicidal thoughts or severe worsening of depression Signs of allergic reaction (rash, swelling, difficulty breathing) Severe dehydration from vomiting or diarrhoea Confusion, severe headache, or seizures (possible hyponatraemia) Unusual bleeding or bruising Symptoms of serotonin syndrome (agitation, confusion, rapid heart rate, high fever, muscle rigidity) this is a risk when sertraline is combined with other serotonergic medications, not with Saxenda alone Never stop either medication abruptly without medical guidance