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For example, with the irreversible BTK inhibitor CC-292, plasma levels fell to near or below the lower limit of quantification within 24 hours post-dose, yet target occupancy remained high for up to 24 hours and declined only as BTK was resynthesized.2 This illustrates the decoupling of PK and PD for covalent drugs and shows that optimizing plasma exposure is less critical than achieving sufficient initial target engagement
Environ Sci Water Res Technol 6(6):15201537 Bolan N et al (2022) Multifunctional applications of biochar beyond carbon storage