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Several other next-generation medications are also in development, each approaching weight management from different angles: Retatrutide is a new medication from Eli Lilly in trials that targets three hormones that control appetite and metabolism

They work by reducing appetite and improving insulin sensitivity, but they do not address the root causes of weight gain, such as inactivity, lack of strength, and slamming a sleeve of Thin Mints for breakfast

Overexpression of GLP-1 in skeletal muscle can improve endurance

How tirzepatide differs Tirzepatide takes the concept further by activating both GLP-1 and GIP receptors simultaneously