Nutrients 6, 2552-2571 (2014)
GLP-1 Agonists Show Promise in Treating Substance Use Disorders Nov 7, 2025 5 min read Updated: Dec 17, 2025 In recent years, medications originally developed to treat Type 2 diabetes, obesity, and other weight-related conditionssuch as semaglutide and liraglutideare showing promise in treating substance use disorders (SUDs)
doi: 10.1002/dmrr.3070 [DOI] [PubMed] [Google Scholar] Associated Data This section collects any data citations, data availability statements, or supplementary materials included in this article
Two primary controllers are peptide hormones produced by the brains hypothalamus, growth hormone releasing hormone (GHRH) and somatostatin, which act in a dynamic equilibrium to regulate circulating GH levels: when the hypothalamus detects reduced blood levels of GH, it releases GHRH which stimulates specialized cells in the pituitary to synthesize and secrete GH