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The continued treatment with 1 M was done as this concentration is within range of the serum concentrations of the sum of tamoxifen and its metabolites in breast cancer patients treated with tamoxifen [24]

Acknowledgements This research was funded by the Guangdong Provincial Department of Education as a scientific research project (2024KQNCX133), Zhanjiang Marine Youth Talent Project (2024R3004), the National Natural Science Foundation of China (82103834) and the Innovative Research Group of Functional Food Development and Quality Analysis (ZY24PYTD05)

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