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2.6 Apoptosis assay A375 human melanoma cells (1 10 4 ) were seeded into white 96-well plates and cultured for 24 h at 37 C with 5% CO 2

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Example gradual titration (5/5 vial, once daily SC) - research reference only Weeks 1-2 Tesamorelin 167 mcg Ipamorelin 167 mcg Units (0.10 mL = 10u) 10 units (0.10 mL) Weeks 3-4 Tesamorelin 333 mcg Ipamorelin 333 mcg Units (0.10 mL = 10u) 20 units (0.20 mL) Weeks 5-8 Tesamorelin 500 mcg Ipamorelin 500 mcg Units (0.10 mL = 10u) 30 units (0.30 mL) Weeks 9-16 Tesamorelin 667 mcg Ipamorelin 667 mcg Units (0.10 mL = 10u) 40 units (0.40 mL) Illustrative titration for the 5/5 vial only

Neuroplasticity driven by HGF/c-Met signaling includes upregulation of brain-derived neurotrophic factor (BDNF), activation of postsynaptic density protein-95 (PSD-95), and increased expression of GluN2B-containing NMDA receptors